Hoip stat1
NettetForsiden - regjeringen.no Nettet20. sep. 2024 · HOIP, an E3 ligase, attaches linear polyubiquitin chains on IRF3, which activates it to interact with the pro-apoptotic protein, Bax. The activated IRF3-Bax complex translocates to mitochondria...
Hoip stat1
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NettetThe interferon (IFN) family is the most important cytokine of the first line of defense against viral infection. IFN can induce STAT1 phosphorylation, which regulates the expression of IFN downstream genes and IFN-mediated antiviral function. Protein ubiquitination regulates protein levels and signaling pathways delicately, thereby playing very … NettetSTAT1. 这个基因编码的蛋白质是stat蛋白家族的一员。. 在对细胞因子和生长因子的反应中，stat家族成员被受体相关的激酶磷酸化，然后形成homo-或异二聚体，在那里它们作为转录激活因子转移到细胞核。. 该蛋白可被多种配体激活，包括干扰素α、干扰素γ、egf ...
NettetHA-GFP was used as a negative control. (G) Analysis of IRF1 and p-STAT1 in HepG2 cells first transfected with STAT3 siRNA for 2 days, ... made up of HOIP, HOIL and … Nettet2. mar. 2024 · Fig. 1: STAT1 harbors linear ubiquitination mediated by HOIP. a Mass spectrometry analysis of the potential Flag-STAT1-binding proteins. The number of the …
NettetThe C-terminal part of HOIP has a unique linear Ub chain-determining domain (LDD) and a preceding characteristic RBR region, which is composed of a RING1 domain, an in-between-RING motif (IBR), and a RING2 domain (Fig. 1A). Nettet3. apr. 2024 · HOIP, as well as HOIL-1L, belongs to the RBR-type E3 family, and the family E3s reportedly generate polyubiquitin chains through a RING-HECT-hybrid reaction 6. During the linear ubiquitination,...
NettetHOIL-1L-interacting protein (HOIP, also known as RNF31), and Shank-associated RH domain-interacting protein (SHARPIN), has been identi ed as the ubiquitin ligase that …
Nettet8. sep. 2024 · HOIP, together with its accessory binding partners HOIL and SHARPIN, forms the linear ubiquitin chain assembly complex (LUBAC) which synthesizes linear … bob rigby photographicNettet1. des. 2001 · PF16678 HOIP-UBA 1 hit; PF01485 IBR 1 hit; PF09409 PUB 1 hit; PF18486 PUB_1 1 hit; SMART. View protein in SMART; SM00647 IBR 2 hits; SM00547 ZnF_RBZ 3 hits; SUPFAM. SSF143503 PUG domain-like 1 hit; SSF90209 Ran binding protein zinc finger-like 1 hit; SSF57850 RING/U-box 3 hits; MobiDB. clip on deck solar lightsNettet9. mai 2024 · Hybrid organic-inorganic perovskites (HOIPs) have been attracting a great deal of attention due to their versatility of electronic properties and fabrication methods. … clip on deckingNettet6. aug. 2024 · In the presence of MyD88 L252P, HOIP elevation in B-cell lymphomas increased the observed number of genome-wide somatic mutations, many of which resembled known or predicted targets of aberrant somatic hypermutation induced by activation-induced cytidine deaminase, a critical player in normal antibody class-switch … clip on decking lightsNettet18. mar. 2024 · Background: HOIP is the catalytic subunit of the linear ubiquitination chain assembly complex (LUBAC) that is essential for NF-κB signaling and thus proper innate … bob rigby photographic reviewsNettet13. sep. 2024 · HOIP or HOIL-1L deficiency in mice results in embryonic lethality at mid-gestation 24, 25 and SHARPIN deficiency in mice results in immunodeficiency and … bob riggle net worthNettet23. des. 2024 · These GOF- STAT1 mutations cause hyperphosphorylation at tyrosine 701 (Y701) of the STAT1 protein, enhancing its binding to gamma-interferon (IFN-γ) activated sites (GAS) and up-regulation of IFN-stimulated genes (ISGs) in response to IFN-α/β, IFN-γ, and IL-27 stimulation ( 9 ). bob rigby pinhole cameras